
As I now shoot Olympus m4/3 I stay well away from high ISO settings anyway. I don't do any sharpening or noise reduction in Capture One or in any other software because the 2022 ON1 performs both perfectly and much more time efficiently. > ON1 2022 NoNoise+Sharpen > Effects > Export to a size recipe > C1 TIFF which has streamlined my workflow and I don't need Photoshop in my post-processing workflow any more.

So, my very much preferred alternative and my new workflow is C1 base camp > Edit With. Topaz wouldn't load to and from C1 via Photoshop either. The latest version of Capture One is launched today 9th December and it might do what's called a 'Round Robin' trip to and from Topaz but I don't know. If you haven't done so already, check in C1 Preferences that any Topaz listed apps are selected as active plug-ins but I seem to recall that unsatisfactorily some were and some weren't! My base camp RAW converter and local adjustments software, I only shoot RAW, is Capture One (C1) and has been for a long time since Apple stopped developing Aperture.

I no longer use Topaz anything because I much prefer my installed alternatives.
